The 'skip metastasis' in osteosarcoma refers to:

• A Pulmonary metastases at the time of presentation
• B Tumour crossing the physis into the epiphysis
• C Lymphatic spread to regional lymph nodes
• D A separate tumour focus within the same bone, not directly connected to the primary, found intramedullarily ✓

Explanation

Skip metastasis describes a satellite tumour deposit within the same bone (or rarely across the adjacent joint) that is separated from the main tumour mass and not contiguous with it. Its presence indicates more aggressive biology and worsens prognosis significantly. Skip metastases are identified on MRI of the entire bone and alter the surgical plan, often upgrading the lesion to Stage III or requiring amputation when limb salvage margins become inadequate.

Reference: Maheshwari Essential Orthopaedics, 6th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.