A 62-year-old man with hypertension presents with sudden blurring of vision in the left eye. Fundus examination shows flame-shaped hemorrhages confined to the superotemporal quadrant with dilated tortuous veins along that arcade. OCT confirms macular edema secondary to branch retinal vein occlusion. Which trial established the efficacy of monthly intravitreal ranibizumab for this condition?
- A MARINA
- B CRUISE
- C BRAVO ✓
- D SCORE
Correct answer: C. BRAVO
Explanation
The BRAVO trial evaluated monthly ranibizumab versus sham injections for macular edema due to branch retinal vein occlusion and showed significant gains in visual acuity at 6 months. CRUISE was its sister trial for central retinal vein occlusion, which is the most tempting distractor here because the design and drug were identical. MARINA tested ranibizumab in neovascular AMD, and SCORE evaluated triamcinolone rather than ranibizumab.
Reference: Kanski's Clinical Ophthalmology, 9th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.