In retinoblastoma, the International Classification System (IIRC) Group D eyes are characterized by:

• A Small tumors away from foveola and disc, no subretinal or vitreous seeding
• B Diffuse vitreous seeding or subretinal seeding, large endophytic/exophytic tumor ✓
• C Massive subretinal seeding, vitreous seeding, and neovascular glaucoma
• D Large tumor filling more than half the retina with localized seeding

Explanation

IIRC Group D eyes have significant tumor burden: subretinal seeding more than 3 mm from the tumor, or vitreous seeding, or both, along with large endophytic or exophytic tumors. Group A: small tumors (≤3 mm) away from foveola and disc. Group B: larger tumors or subretinal fluid without seeding. Group C: focal subretinal or vitreous seeding (≤3 mm). Group E: very advanced eyes with neovascular glaucoma, opaque media, or gross orbital involvement — often requiring enucleation. Groups D and E have the lowest globe salvage rates with intra-arterial or intravitreal chemotherapy.

Reference: Khurana Comprehensive Ophthalmology, 7th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.