Sorafenib and sunitinib (oral anti-VEGF tyrosine kinase inhibitors) were found to be associated with which ocular complication as a class effect?

• A Exudative (serous) retinal detachment and retinal pigment epithelial detachment ✓
• B Anterior uveitis and hypotony
• C Central retinal artery occlusion
• D Corneal verticillata

Explanation

Oral multikinase/anti-VEGF inhibitors (sorafenib, sunitinib, pazopanib) are associated with exudative retinal detachment and retinal pigment epithelial detachments as a class effect, likely due to disruption of RPE-choriocapillaris VEGF homeostasis needed for photoreceptor survival. These are generally reversible on drug cessation. Corneal verticillata (whorl-shaped corneal deposits) is associated with amiodarone and hydroxychloroquine. Anterior uveitis is linked to rifabutin and immune checkpoint inhibitors. This class effect requires monitoring during systemic oncology treatment.

Reference: Khurana Comprehensive Ophthalmology, 7th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.