In retinoblastoma, the International Classification (IIRC) Group E eye is defined by the presence of:

• A Any tumor with vitreous or subretinal seeding
• B Tumor >3 mm or any tumor touching the optic disc
• C Any tumor without seeding regardless of size
• D Extensive tumor occupying >50% of globe with or without neovascular glaucoma, opaque media, or phthisis ✓

Explanation

The International Intraocular Retinoblastoma Classification (IIRC) Group E represents the most advanced intraocular disease: tumors occupying >50% of the vitreous cavity, neovascular glaucoma, opaque media from haemorrhage, tumour in anterior segment, diffuse infiltrating retinoblastoma, phthisis or pre-phthisis bulbi. These eyes have poor prognosis for vision and typically require primary enucleation. Group D involves extensive seeding (vitreous or subretinal snowballs/plaques) but without the endpoint features of Group E.

Reference: Khurana Comprehensive Ophthalmology, 7th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.