In rhegmatogenous retinal detachment, subretinal fluid accumulation occurs due to which primary physiological mechanism?

• A Active transport failure of RPE causing fluid accumulation from choroidal leakage
• B Increased hydrostatic pressure in the subretinal space from choroidal neovascularization
• C Osmotic pressure gradient pulling fluid from the vitreous into the subretinal space
• D Liquefied vitreous passing through a retinal break combined with reduced RPE pump function ✓

Explanation

In rhegmatogenous RD, liquefied vitreous (synchysis) passes through a full-thickness retinal break into the subretinal space. Simultaneously, the normal dehydrating action of the RPE (which actively pumps water from the subretinal space toward the choroid) is overwhelmed or insufficient to counteract the fluid ingress. This two-component mechanism (vitreous liquefaction + break + RPE pump insufficiency) distinguishes rhegmatogenous from exudative or tractional RD.

Reference: Khurana Comprehensive Ophthalmology, 7th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.