During retinopathy of prematurity screening, an infant is noted to have marked dilation and tortuosity of the posterior pole retinal veins with secondary arteriolar tortuosity involving two quadrants. How should this finding be classified?

• A Stage 3 ROP
• B Plus disease ✓
• C Aggressive posterior ROP
• D Zone II immature vasculature

Explanation

Plus disease is defined as increased venous dilation and arteriolar tortuosity of the posterior pole vessels, originally requiring involvement of at least two quadrants. It signifies shunting of blood through dilated peripheral vessels and is the strongest indicator for treatment regardless of stage or zone. Stage 3 describes extraretinal fibrovascular proliferation, aggressive posterior ROP is a fulminant form located in zone I or posterior zone II, and vascular immaturity alone does not produce this degree of tortuosity.

Reference: Khurana, Comprehensive Ophthalmology, 7th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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