Age-related macular degeneration (AMD) — the 'wet' (exudative) form differs from dry AMD in that wet AMD is characterised by:
- A Choroidal neovascularisation (CNV) with subretinal or sub-RPE fluid and haemorrhage ✓
- B Hard drusen and RPE atrophy
- C Geographic atrophy of the RPE and choriocapillaris
- D Drusenoid RPE detachment without neovascularisation
Correct answer: A. Choroidal neovascularisation (CNV) with subretinal or sub-RPE fluid and haemorrhage
Explanation
Wet (exudative/neovascular) AMD is defined by the presence of choroidal neovascularisation (CNV), which breaks through Bruch's membrane into the sub-RPE or subretinal space, causing exudation of fluid and haemorrhage leading to rapid visual loss. Dry AMD encompasses drusen (hard and soft), RPE abnormalities, and geographic atrophy. Treatment of wet AMD centres on anti-VEGF injections (ranibizumab, aflibercept, bevacizumab, brolucizumab, faricimab).
Reference: Khurana Comprehensive Ophthalmology, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.