In the CRYO-ROP and ETROP studies, the threshold for treatment of ROP was revised. According to ETROP, treatment is recommended for which type of ROP?
- A Stage 2 ROP in any zone without plus disease
- B Only Stage 5 (total retinal detachment) regardless of zone
- C Type 1 ROP (Zone I any stage with plus disease; Zone I Stage 3 without plus; Zone II Stage 2 or 3 with plus disease) ✓
- D All ROP with plus disease regardless of stage or zone
Correct answer: C. Type 1 ROP (Zone I any stage with plus disease; Zone I Stage 3 without plus; Zone II Stage 2 or 3 with plus disease)
Explanation
The ETROP (Early Treatment for Retinopathy of Prematurity) study defined 'Type 1 ROP' as cases warranting immediate treatment: Zone I — any stage ROP with plus disease; Zone I — Stage 3 ROP without plus; Zone II — Stage 2 or 3 with plus disease. 'Type 2 ROP' (Zone I Stage 1 or 2 without plus; Zone II Stage 3 without plus) requires observation only. This refined the older CRYO-ROP threshold (Stage 3+ in Zone II/III), allowing earlier treatment and better visual outcomes. Treatment modality is intravitreal anti-VEGF (bevacizumab/ranibizumab) or laser photocoagulation.
Reference: Khurana Comprehensive Ophthalmology, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.