A premature infant born at 28 weeks gestation weighing 1100 g is screened for retinopathy of prematurity (ROP). Stage 3 ROP is found in zone II with plus disease. According to current ICROP3 criteria, the appropriate treatment threshold (treatment-warranted ROP) is:

• A Stage 2 zone II with pre-plus disease
• B Stage 4A zone I without plus disease
• C Stage 3 zone II with plus disease ✓
• D Stage 1 zone I with aggressive posterior ROP (AP-ROP) features

Explanation

Treatment-warranted ROP (T-W ROP) as per updated ICROP3 (2021) classification replaces the older 'threshold' terminology. T-W ROP includes: any stage in zone I with plus disease; stage 3 in zone I without plus; stage 2 or 3 in zone II with plus disease; or aggressive ROP (A-ROP, formerly AP-ROP) in any zone. Stage 3 zone II with plus disease clearly meets T-W ROP criteria requiring intervention (intravitreal anti-VEGF or laser). Stage 4A detachment without plus does not meet threshold independently.

Reference: Khurana Comprehensive Ophthalmology, 7th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.