In the management of a moderate to severe alkali corneal burn after adequate irrigation, which supplement is given systemically or topically to inhibit collagenolysis and reduce the risk of corneal melting?

• A Ascorbic acid ✓
• B Atropine sulphate
• C Sodium chloride 5% drops
• D Prednisolone acetate 1% used continuously for 6 weeks

Explanation

Alkali burns deplete corneal ascorbate, impairing collagen synthesis by keratocytes, while polymorphonuclear influx drives collagenase-mediated stromal melting. Ascorbic acid supplementation restores collagen production and reduces perforation risk, and citrate acts as a PMN inhibitor. Atropine aids comfort and prevents synechiae but does not affect collagenolysis. Corticosteroids reduce inflammation but increase melt risk when used beyond 10 days, so continuous prolonged steroid use is harmful.

Reference: Parsons' Diseases of the Eye, 23rd ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.