A 55-year-old man undergoes repair of an open globe injury (corneoscleral laceration) within 24 hours of trauma. According to current evidence, intravenous antibiotic prophylaxis for post-traumatic endophthalmitis should cover which combination?
- A Intramuscular ceftriaxone
- B Topical moxifloxacin alone
- C Vancomycin plus ceftazidime ✓
- D Oral ciprofloxacin alone
Correct answer: C. Vancomycin plus ceftazidime
Explanation
The landmark study on open globe injuries found that intravenous vancomycin plus ceftazidime (or an equivalent antipseudomonal beta-lactam) for 48 to 96 hours significantly reduced the rate of post-traumatic endophthalmitis. Topical or oral monotherapy alone does not provide adequate intravitreal penetration for prophylaxis in this high-risk setting.
Reference: AAO BCSC Section 9: Uveitis and Ocular Inflammation, 2023-2024 ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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