The standard dose and volume of intravitreal bevacizumab used for wet age-related macular degeneration is:
- A 0.5 mg in 0.05 mL
- B 1.25 mg in 0.05 mL ✓
- C 2.0 mg in 0.08 mL
- D 4 mg in 0.1 mL
Correct answer: B. 1.25 mg in 0.05 mL
Explanation
Bevacizumab is drawn from the 100 mg per 4 mL vial and injected intravitreally as 0.05 mL containing 1.25 mg. Ranibizumab uses 0.5 mg in 0.05 mL, and aflibercept uses 2 mg in 0.05 mL, which makes option C tempting but wrong because 0.08 mL is not the aflibercept volume either. Knowledge of these doses matters because compounding errors leading to overdose have caused toxic anterior segment syndrome and retinal damage.
Reference: Khurana's Comprehensive Ophthalmology, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.