Among the prostaglandin analogue class of anti-glaucoma drugs, the agent with the additional property of selective FP receptor agonism AND EP3 receptor agonism, giving it uveoscleral AND trabecular outflow enhancement, is:
- A Latanoprost
- B Travoprost
- C Bimatoprost (prostamide) ✓
- D Unoprostone
Correct answer: C. Bimatoprost (prostamide)
Explanation
Bimatoprost is classified as a prostamide (an amide analogue of prostaglandin) rather than a pure FP agonist. It acts on the prostamide receptor (which is distinct from classic FP receptors) and, through this mechanism and possible FP receptor partial agonism, enhances both uveoscleral outflow AND trabecular (conventional) outflow — unlike latanoprost and travoprost which primarily enhance uveoscleral outflow. This dual mechanism gives bimatoprost slightly greater IOP-lowering efficacy in some studies. Unoprostone has the weakest IOP-lowering effect in this class.
Reference: Khurana Comprehensive Ophthalmology, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.