Which intravitreal anti-VEGF agent binds VEGF-A, VEGF-B, AND placental growth factor (PlGF), giving it the broadest VEGF-family binding profile among currently approved agents?
- A Ranibizumab
- B Bevacizumab
- C Aflibercept ✓
- D Brolucizumab
Correct answer: C. Aflibercept
Explanation
Aflibercept (VEGF Trap) is a fusion protein combining the binding domains of VEGFR-1 and VEGFR-2 fused to the Fc of IgG1. It binds VEGF-A (all isoforms), VEGF-B, and PlGF — the broadest VEGF-family profile. Ranibizumab and bevacizumab bind only VEGF-A. Brolucizumab is a single-chain antibody fragment (scFv) that binds VEGF-A only (with very high affinity).
Reference: Khurana Comprehensive Ophthalmology, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.