Which topical steroid preparation has the LOWEST potential for raising intraocular pressure (steroid-response) while retaining reasonable anti-inflammatory efficacy in the anterior segment?
- A Prednisolone acetate 1%
- B Dexamethasone 0.1%
- C Loteprednol etabonate 0.5% ✓
- D Betamethasone 0.1%
Correct answer: C. Loteprednol etabonate 0.5%
Explanation
Loteprednol etabonate is a 'soft' corticosteroid designed to undergo predictable ester hydrolysis to an inactive metabolite once it penetrates ocular tissues, minimising the glucocorticoid effect on trabecular meshwork. It has significantly lower IOP-elevating potential compared to prednisolone acetate, dexamethasone, or betamethasone while retaining anterior segment anti-inflammatory activity. It is particularly preferred in steroid-responders and for maintenance therapy.
Reference: Khurana Comprehensive Ophthalmology, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.