Which ocular side effect is UNIQUE to brimonidine (alpha-2 agonist) eye drops when used in neonates and young infants?
- A Hyperpigmentation of iris
- B Apnoea and CNS depression ✓
- C Punctate keratitis and follicular conjunctivitis
- D Eyelash hypertrichosis and periocular hyperpigmentation
Correct answer: B. Apnoea and CNS depression
Explanation
Brimonidine crosses the blood-brain barrier readily in neonates and young infants (immature BBB), causing profound CNS depression manifesting as apnoea, hypotension, bradycardia, hypothermia, and somnolence. It is therefore contraindicated in children under 2 years. Iris hyperpigmentation and eyelash hypertrichosis are side effects of prostaglandin analogues. Follicular conjunctivitis is a known long-term side effect of brimonidine in adults.
Reference: Khurana Comprehensive Ophthalmology, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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