Which prostaglandin analogue has a dual mechanism of action — both FP receptor agonism and EP2/EP3 receptor activity — and is available as a preservative-free formulation?
- A Latanoprostene bunod ✓
- B Latanoprost
- C Bimatoprost
- D Tafluprost
Correct answer: A. Latanoprostene bunod
Explanation
Latanoprostene bunod (Vyzulta) is a nitric oxide-donating prostaglandin analogue — it is cleaved in the eye to latanoprost acid (FP receptor agonist increasing uveoscleral outflow) and butanediol mononitrate (releases NO, which activates soluble guanylate cyclase, increasing trabecular outflow via the NO-cGMP pathway). This dual mechanism targets both uveoscleral and trabecular outflow pathways. Tafluprost is a preservative-free prostaglandin but works solely via FP receptors. Bimatoprost is a prostamide.
Reference: Khurana Comprehensive Ophthalmology, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.