A 45-year-old woman with FIGO 2018 Stage IIB cervical cancer (parametrial involvement present) is planned for definitive chemoradiation. The external beam radiotherapy is planned to 45 Gy in 25 fractions. What is the recommended cumulative equivalent dose (EQD2) to Point A required for optimal local control?
- A 30-35 Gy
- B 45-50 Gy
- C 75-85 Gy ✓
- D 95-100 Gy
Correct answer: C. 75-85 Gy
Explanation
The cumulative EQD2 (equivalent dose in 2 Gy fractions) to Point A, combining external beam radiotherapy and brachytherapy, should be ≥85 Gy (range 75-85 Gy is acceptable) for optimal local control in locally advanced cervical cancer. Inadequate dose is associated with higher recurrence rates. Brachytherapy is essential to boost the central tumor dose beyond what EBRT alone can safely deliver.
Reference: Perez and Brady's Principles and Practice of Radiation Oncology, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.