A 33-year-old woman with Peutz-Jeghers syndrome undergoes hysterectomy for a cervical lesion. Histology shows endocervical glands lined by well-differentiated mucin-producing cells with minimal cytological atypia infiltrating deeply into the cervical stroma. Which variant of cervical adenocarcinoma is this?
- A Adenoid cystic carcinoma
- B Clear cell adenocarcinoma
- C Minimal deviation adenocarcinoma (adenoma malignum) ✓
- D Mucinous adenocarcinoma, intestinal type
Correct answer: C. Minimal deviation adenocarcinoma (adenoma malignum)
Explanation
Minimal deviation adenocarcinoma, historically called adenoma malignum, is a highly differentiated gastric-type mucinous adenocarcinoma in which glands appear deceptively benign yet invade deeply. It is classically associated with Peutz-Jeghers syndrome and carries a poor prognosis because diagnosis is delayed. Clear cell carcinoma is linked to intrauterine DES exposure, adenoid cystic carcinoma shows a cribriform pattern with basaloid cells, and intestinal-type mucinous tumours contain goblet cells.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.