A 15-year-old girl is brought for HPV vaccination. Her mother asks how many oncogenic HPV types the nonavalent vaccine protects against. The nonavalent (9-valent) HPV vaccine provides protection against which set of HPV types?
- A 6, 11, 16, 18, 31, 33, 45, 52 and 58 ✓
- B 16, 18, 31, 33 and 45 only
- C 6, 11, 16 and 18 only
- D 16, 18, 35, 39, 51, 56, 58 and 59
Correct answer: A. 6, 11, 16, 18, 31, 33, 45, 52 and 58
Explanation
The 9-valent vaccine covers the two low-risk types 6 and 11 plus seven oncogenic types: 16, 18, 31, 33, 45, 52 and 58. Together these account for approximately 90 percent of cervical cancers. Option C describes the quadrivalent vaccine and option B approximates the bivalent plus additional coverage, both of which protect against fewer types. Types listed in option D belong to the group of other high-risk types not included in any licensed vaccine.
Reference: Williams Gynecology, 4th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.