Which HPV types are classified as 'probably carcinogenic' (Group 2A) by IARC rather than 'definitely carcinogenic' (Group 1)?
- A HPV 68 ✓
- B HPV 16
- C HPV 18
- D HPV 45
Correct answer: A. HPV 68
Explanation
IARC classifies HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59 as Group 1 (definitely carcinogenic). HPV 68 is classified as Group 2A (probably carcinogenic), reflecting less definitive evidence for its independent causal role. HPV 16 and 18 cause approximately 70% of cervical cancers; HPV 45 is Group 1. This distinction is relevant for understanding the limitations of current nonavalent vaccine coverage.
Reference: Shaw's Textbook of Gynaecology, 17th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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