Which HPV genotype combination accounts for the greatest proportion of cervical cancers worldwide?
- A HPV 16 and HPV 18 ✓
- B HPV 6 and HPV 11
- C HPV 31 and HPV 33
- D HPV 45 and HPV 52
Correct answer: A. HPV 16 and HPV 18
Explanation
HPV 16 and HPV 18 together account for approximately 70% of all cervical cancers globally — HPV 16 alone accounts for ~50% and HPV 18 for ~15–20%. HPV 6 and 11 cause genital warts (low-risk). HPV 31, 33, 45, 52, and 58 are additional high-risk types covered by the nonavalent vaccine but contribute a smaller proportion of cervical cancers.
Reference: Shaw's Textbook of Gynaecology, 17th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.