In cervical cancer screening, co-testing with HPV and cytology is preferred over cytology alone. The MOST carcinogenic HPV genotypes responsible for approximately 70% of cervical cancers are:

• A HPV 6 and 11
• B HPV 16 and 18 ✓
• C HPV 31 and 33
• D HPV 45 and 52

Explanation

HPV 16 and 18 together account for approximately 70% of cervical cancers worldwide; HPV 16 causes predominantly squamous cell carcinoma while HPV 18 is more strongly associated with adenocarcinoma. HPV 6 and 11 are low-risk types causing genital warts (condylomata acuminata). HPV 31, 33, 45, 52, and 58 are intermediate-risk types covered by the 9-valent vaccine.

Reference: Shaw's Textbook of Gynaecology, 17th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.