Which HPV genotype combination accounts for approximately 70% of cervical cancer cases worldwide?
- A HPV 16 and 18 ✓
- B HPV 16 and 31
- C HPV 18 and 45
- D HPV 16, 18, and 45
Correct answer: A. HPV 16 and 18
Explanation
HPV types 16 and 18 together account for approximately 70% of all cervical cancers globally. HPV 16 predominantly causes squamous cell carcinoma, while HPV 18 is more strongly associated with adenocarcinoma. Types 31, 33, 45, 52, and 58 account for an additional ~15%. The quadrivalent and bivalent vaccines target HPV 16 and 18, and the nonavalent vaccine additionally covers types 31, 33, 45, 52, and 58.
Reference: Shaw's Textbook of Gynaecology, 17th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.