The GOG 120 trial established concurrent cisplatin-based chemoradiation as superior to radiation alone for cervical cancer. Which regimen was NOT included in GOG 120?
- A Weekly cisplatin 40 mg/m²
- B Hydroxyurea
- C Carboplatin + paclitaxel ✓
- D Cisplatin + 5-FU + hydroxyurea
Correct answer: C. Carboplatin + paclitaxel
Explanation
GOG 120 compared three arms: (1) weekly cisplatin 40 mg/m², (2) hydroxyurea alone, and (3) cisplatin + 5-FU + hydroxyurea — all with pelvic radiation. Weekly cisplatin and the triple-drug arm both outperformed hydroxyurea alone, establishing concurrent cisplatin as the standard. Carboplatin + paclitaxel was not part of GOG 120; this doublet is used in recurrent/metastatic cervical cancer (GOG 240 added bevacizumab to this backbone).
Reference: Shaw's Textbook of Gynaecology, 17th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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