The LACC trial (2018, NEJM) compared minimally invasive radical hysterectomy to open radical hysterectomy for early-stage cervical cancer and found:
- A Superior disease-free survival with minimally invasive approach
- B Significantly lower disease-free survival and higher recurrence with minimally invasive surgery ✓
- C Equivalent outcomes between laparoscopic and open surgery
- D Higher intraoperative complications with open surgery
Correct answer: B. Significantly lower disease-free survival and higher recurrence with minimally invasive surgery
Explanation
The LACC (Laparoscopic Approach to Cervical Cancer) trial was a landmark RCT that unexpectedly showed minimally invasive radical hysterectomy was associated with significantly lower disease-free survival (3-year DFS 91.2% vs 97.1%), higher recurrence rates, and higher mortality compared to open abdominal radical hysterectomy. This finding reversed the presumed equivalence and has led to open surgery remaining the standard of care for radical hysterectomy in cervical cancer.
Reference: Shaw's Textbook of Gynaecology, 17th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.