The Papanicolaou (Pap) smear has highest sensitivity for detecting which cervical lesion?
- A CIN 2/3 (high-grade squamous intraepithelial lesion) ✓
- B CIN 1
- C Adenocarcinoma in situ of the cervix
- D Microinvasive squamous carcinoma Stage IA1
Correct answer: A. CIN 2/3 (high-grade squamous intraepithelial lesion)
Explanation
Cytological sensitivity is highest for high-grade squamous intraepithelial lesions (CIN 2/3 / HSIL), where exfoliated dysplastic cells are more numerous and morphologically distinct. CIN 1 has lower sensitivity because many cases regress and shed fewer abnormal cells. Adenocarcinoma in situ has notoriously poor cytological detection due to glandular crypts. Microinvasive carcinoma may not exfoliate sufficient abnormal cells.
Reference: Shaw's Textbook of Gynaecology, 17th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.