Regarding sentinel lymph node (SLN) mapping in early-stage cervical cancer, which dye/technique combination is currently considered most sensitive?
- A Patent blue dye alone injected into the cervix
- B Technetium-99m radiocolloid alone
- C Indocyanine green (ICG) with near-infrared fluorescence ✓
- D Methylene blue injected intracervically
Correct answer: C. Indocyanine green (ICG) with near-infrared fluorescence
Explanation
Sentinel lymph node mapping in early cervical cancer (Stage IA1–IB2) has been validated in prospective studies (SENTICOL, FILM). Indocyanine green (ICG) detected with near-infrared fluorescence imaging shows the highest detection rates, with bilateral SLN detection rates exceeding 90%, superior to blue dye or radioisotope alone. ICG allows real-time intraoperative fluorescence guidance and is particularly useful in minimally invasive (robotic) radical hysterectomy.
Reference: Shaw's Textbook of Gynaecology, 17th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.