The HPV genotypes responsible for approximately 70% of cervical cancers globally are:

• A HPV 6 and 11
• B HPV 16 and 18 ✓
• C HPV 31 and 33
• D HPV 45 and 52

Explanation

HPV 16 and 18 together account for approximately 70% of invasive cervical cancers worldwide, with HPV 16 being the single most common type (~50-60%) and HPV 18 adding another 10-15%. HPV 6 and 11 cause genital warts (condyloma acuminata) and are low-risk types not associated with cancer. HPV 31, 33, 45, 52, and 58 are other high-risk types collectively covered by the nonavalent vaccine. The quadrivalent vaccine (Gardasil) covers HPV 6, 11, 16, and 18; the bivalent vaccine (Cervarix) covers 16 and 18.

Reference: Shaw's Textbook of Gynaecology, 17th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.