In the LACC (Laparoscopic Approach to Cervical Cancer) trial, minimally invasive radical hysterectomy for early-stage cervical cancer was associated with compared to open surgery:

• A Equivalent disease-free and overall survival with less blood loss
• B Improved overall survival but equivalent recurrence rates
• C Significantly lower disease-free survival (3-year DFS 91.2% vs 97.1%) and higher recurrence rates ✓
• D Higher recurrence only in Stage IB2 patients but not IB1

Explanation

The LACC trial (NEJM 2018) was a landmark RCT demonstrating that minimally invasive radical hysterectomy (laparoscopic or robotic) for early-stage cervical cancer had significantly worse outcomes than open surgery. The 3-year disease-free survival was 91.2% in the minimally invasive group versus 97.1% in the open surgery group, and the minimally invasive group had a 4-fold higher rate of death from cervical cancer. This trial reversed the trend toward minimally invasive approaches for cervical cancer and resulted in most centres returning to open radical hysterectomy as the standard of care.

Reference: Shaw's Textbook of Gynaecology, 17th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.