Which intermediate-risk factor for recurrence after radical hysterectomy for early-stage cervical cancer is identified in the 'Sedlis criteria' for adjuvant radiotherapy?
- A Positive surgical margins
- B Parametrial involvement
- C Combination of large tumor size, deep stromal invasion, and lymphovascular space invasion ✓
- D Pelvic lymph node metastasis
Correct answer: C. Combination of large tumor size, deep stromal invasion, and lymphovascular space invasion
Explanation
The Sedlis criteria (from GOG 92 trial) define intermediate-risk factors for adjuvant pelvic radiotherapy after radical hysterectomy for cervical cancer: combination of tumor size, depth of cervical stromal invasion (inner/middle/deep thirds), and lymphovascular space invasion (LVSI). Positive margins, parametrial involvement, and lymph node metastases are 'high-risk' factors (Peters criteria from GOG 109) indicating adjuvant concurrent chemoradiation rather than radiation alone.
Reference: Shaw's Textbook of Gynaecology, 17th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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