Which HPV genotypes are covered by the 9-valent HPV vaccine (Gardasil-9), in addition to the types 6, 11, 16, and 18 covered by the quadrivalent vaccine?

• A Types 31, 33, 45, 51, and 56
• B Types 26, 33, 45, 52, and 58
• C Types 31, 33, 52, 58, and 66
• D Types 31, 33, 45, 52, and 58 ✓

Explanation

The 9-valent HPV vaccine (Gardasil-9) covers HPV types 6, 11, 16, 18 (from the quadrivalent) PLUS five additional high-risk oncogenic types: 31, 33, 45, 52, and 58. Together, types 16, 18, 31, 33, 45, 52, and 58 account for approximately 90% of cervical cancers globally. The bivalent vaccine (Cervarix) covers only 16 and 18.

Reference: Shaw's Textbook of Gynaecology, 17th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.