Which landmark trial (KEYS study / GOG 123) established concurrent cisplatin-based chemoradiation as the standard of care for locally advanced cervical cancer, replacing radiation alone?

• A GOG 85
• B GOG 120
• C SENTICOL trial
• D GOG 123 (KEYS trial) ✓

Explanation

The GOG 123 (KEYS) trial, along with concurrent landmark studies (GOG 85, GOG 120, RTOG 90-01), established that concurrent cisplatin-based chemotherapy with pelvic radiation significantly improved survival compared with radiation alone in locally advanced cervical cancer. GOG 123 specifically compared radiation alone with concurrent cisplatin-radiation for bulky stage IB disease. SENTICOL evaluated sentinel lymph node biopsy in early-stage cervical cancer.

Reference: Shaw's Textbook of Gynaecology, 17th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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