Liver biopsy from a patient who returned from South America with fever, jaundice and oliguria shows midzonal necrosis with eosinophilic apoptotic hepatocytes and minimal inflammation. These eosinophilic degenerating hepatocytes are known as:
- A Mallory-Denk bodies
- B Councilman bodies ✓
- C Ground-glass hepatocytes
- D Warthin-Finkeldey giant cells
Correct answer: B. Councilman bodies
Explanation
Yellow fever produces a characteristic midzonal hepatic necrosis containing Councilman bodies, which are eosinophilic apoptotic hepatocytes, along with microvesicular fatty change. Notably, inflammatory infiltration is characteristically minimal despite severe necrosis. Mallory-Denk bodies occur in alcoholic steatohepatitis, ground-glass hepatocytes reflect chronic hepatitis B surface antigen accumulation, and Warthin-Finkeldey giant cells are the multinucleate lymphoid cells of measles.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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