A 30-year-old HIV-positive man with a CD4 count of 40 cells/μL presents with multiple violaceous nodular skin lesions and bilateral lower-limb edema. HHV-8 (KSHV) is implicated in the pathogenesis. Which malignancy is most strongly associated with this presentation?
- A Kaposi sarcoma ✓
- B Primary effusion lymphoma
- C Castleman disease
- D Burkitt lymphoma
Correct answer: A. Kaposi sarcoma
Explanation
The violaceous skin lesions with edema in an advanced HIV patient are classic for AIDS-related Kaposi sarcoma caused by HHV-8 (KSHV). HHV-8 is detected in all epidemiological forms of Kaposi sarcoma. Primary effusion lymphoma is also HHV-8 associated but presents with serous effusions, not skin nodules. Castleman disease is HHV-8 associated but presents with lymphadenopathy. Burkitt lymphoma is associated with EBV, not HHV-8, though HIV is a cofactor.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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