Chronic granulomatous invasive fungal sinusitis, seen mainly in North Africa and Sudan, is characteristically caused by which organism?
- A Mucor circinelloides
- B Rhizopus arrhizus
- C Aspergillus flavus ✓
- D Fusarium solani
Correct answer: C. Aspergillus flavus
Explanation
The granulomatous form of chronic invasive fungal sinusitis, also called paranasal granuloma, occurs predominantly in Sudan and surrounding regions and is almost always due to Aspergillus flavus. Histology shows noncaseating granulomas with giant cells and scattered hyphae. Rhizopus and Mucor species cause the acute fulminant angioinvasive disease of diabetics rather than indolent granulomatous disease, and Fusarium is associated with neutropenic hosts, making these distractors wrong on both organism and behaviour.
Reference: Scott-Brown's Essential Otorhinolaryngology, 3rd ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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