Allergic fungal rhinosinusitis (AFRS) is characterized by which pathological finding on histology and mucin analysis?
- A Tissue invasion by fungal hyphae with granuloma formation
- B Neutrophilic infiltrate with hyphal invasion of blood vessels
- C Eosinophilic mucin with Charcot-Leyden crystals and non-invasive fungal hyphae ✓
- D Caseous necrosis with acid-fast bacilli
Correct answer: C. Eosinophilic mucin with Charcot-Leyden crystals and non-invasive fungal hyphae
Explanation
AFRS is a non-invasive, eosinophilic-driven condition. Characteristic pathology shows thick, inspissated eosinophilic mucin ('allergic mucin') containing Charcot-Leyden crystals (products of degranulated eosinophils) and sparse, non-invasive fungal hyphae (most commonly Bipolaris, Curvularia, or Aspergillus). There is no tissue invasion — this differentiates it from invasive fungal sinusitis. Elevated total IgE and fungal-specific IgE support the diagnosis.
Reference: Dhingra Diseases of Ear, Nose and Throat, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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