In allergic fungal rhinosinusitis (AFRS), which of the following histopathological findings on nasal polypectomy is pathognomonic?
- A Charcot-Leyden crystals and allergic mucin with non-invasive fungal hyphae ✓
- B Dense fibrous tissue with plasma cell infiltration
- C Granuloma formation with Langhans giant cells
- D Pseudomembrane with tissue invasion by branching hyphae
Correct answer: A. Charcot-Leyden crystals and allergic mucin with non-invasive fungal hyphae
Explanation
AFRS is characterised by eosinophilic allergic mucin containing degenerate eosinophils (Charcot-Leyden crystals), non-invasive fungal hyphae within the mucin, and surrounding eosinophilic polyps. Tissue invasion is absent — this distinguishes AFRS from invasive fungal sinusitis. Langhans giant cells suggest granulomatous disease (e.g., TB, sarcoid). Fibrous tissue with plasma cells is seen in fibrosing conditions.
Reference: Dhingra Diseases of Ear, Nose and Throat, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.