Nasopharyngeal carcinoma has a striking geographical and ethnic predilection. Besides genetic susceptibility, which dietary factor is strongly implicated in its pathogenesis?
- A High intake of smoked meat
- B Consumption of Cantonese-style salted fish ✓
- C Aflatoxin-contaminated grains
- D High intake of nitrosamine-rich pickled vegetables
Correct answer: B. Consumption of Cantonese-style salted fish
Explanation
Cantonese-style salted fish is classified as a Group 1 carcinogen for nasopharyngeal carcinoma by the IARC. It contains N-nitrosamines that damage nasopharyngeal epithelium. Aflatoxin is linked to hepatocellular carcinoma. Smoked meat and pickled vegetables are associated with gastric and esophageal cancers but are not the primary dietary risk factor for NPC.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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