A 55-year-old woman presents with dysphagia to solids, pallor, and koilonychia. Barium swallow shows a thin, circumferential web in the post-cricoid region. She is diagnosed with Plummer-Vinson syndrome (Paterson-Brown-Kelly syndrome). What is the most significant long-term complication these patients are at increased risk of developing?
- A Squamous cell carcinoma of the post-cricoid region ✓
- B Esophageal adenocarcinoma
- C Adenocarcinoma of the gastroesophageal junction
- D Small cell carcinoma of the esophagus
Correct answer: A. Squamous cell carcinoma of the post-cricoid region
Explanation
Plummer-Vinson syndrome is characterized by the triad of iron-deficiency anemia, esophageal webs, and dysphagia. These patients have a significantly increased risk of developing squamous cell carcinoma in the post-cricoid region of the pharynx/esophagus. This is a well-established association in standard ENT and medicine texts. Adenocarcinoma is associated with Barrett's esophagus, not this syndrome.
Reference: Diseases of Ear, Nose and Head and Neck Surgery, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.