A 45-year-old man presents with progressive midline facial destruction, nasal septal perforation, and foul-smelling necrotic debris. Biopsy shows an angiocentric lymphoid infiltrate with extensive necrosis. Which of the following viral associations is most characteristic of this lesion?
- A Epstein-Barr virus (EBV) ✓
- B Human papillomavirus (HPV)
- C Human herpesvirus 8 (HHV-8)
- D Cytomegalovirus (CMV)
Correct answer: A. Epstein-Barr virus (EBV)
Explanation
Extranodal NK/T-cell lymphoma, nasal type, is characterized by an angiocentric and angiodestructive lymphoid infiltrate causing necrosis, historically termed lethal midline granuloma. It has a strong association with Epstein-Barr virus (EBV). HPV is associated with papillomas and some squamous cell carcinomas. HHV-8 is linked to Kaposi sarcoma. CMV is an opportunistic pathogen not typically associated with this lymphoma.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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