Inverted papilloma of the nasal cavity and paranasal sinuses carries a risk of malignant transformation. The reported rate of synchronous or metachronous squamous cell carcinoma arising from inverted papilloma is approximately:
- A 5–15% (most commonly synchronous) ✓
- B < 1%
- C 30–40%
- D > 50%
Correct answer: A. 5–15% (most commonly synchronous)
Explanation
Inverted papilloma (Schneider papilloma, Type II) has a well-recognized but relatively low (5–15%) risk of synchronous or metachronous squamous cell carcinoma transformation, with most studies reporting around 10%. HPV types 6 and 11 are implicated in benign forms; HPV 16 and 18 in malignant transformation. Management of inverted papilloma without malignancy is wide local excision (endoscopic medial maxillectomy); if SCC is found, standard oncological principles apply including potential radiation.
Reference: Dhingra Diseases of Ear, Nose and Throat, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.