In recurrent respiratory papillomatosis (RRP), the causative HPV types and the preferred medical adjuvant to surgery are:

• A HPV 16 and 18; interferon-alpha as adjuvant
• B HPV 6 and 11; cidofovir or bevacizumab as adjuvant ✓
• C HPV 31 and 33; intralesional bleomycin
• D HPV 16 and 18; topical imiquimod

Explanation

Recurrent respiratory papillomatosis is caused predominantly by HPV types 6 and 11, with HPV 11 associated with a more aggressive course. The primary treatment is repeated microlaryngoscopic excision (cold steel, CO2 laser, or KTP laser) to maintain airway patency. Adjuvant therapies for frequently recurring or aggressive RRP include intralesional cidofovir (antiviral) and bevacizumab (anti-VEGF, inhibits papilloma vascularity). HPV 16 and 18 are associated with malignant transformation in the oropharynx, not benign RRP.

Reference: Dhingra Diseases of Ear, Nose and Throat, 7th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.