A 25-year-old patient presents with recurrent respiratory papillomatosis. Histology shows koilocytes, and HPV typing reveals type 6 and 11. Regarding HPV 11 compared to HPV 6, which statement is correct?
- A HPV 11 is more strongly associated with malignant transformation than HPV 6 ✓
- B HPV 6 has higher oncogenic potential than HPV 11
- C Both subtypes have equal malignant potential
- D Neither HPV 6 nor HPV 11 is associated with recurrent respiratory papillomatosis
Correct answer: A. HPV 11 is more strongly associated with malignant transformation than HPV 6
Explanation
Recurrent respiratory papillomatosis (RRP) is caused by HPV types 6 and 11, both low-risk strains for cervical cancer. However, within RRP itself, HPV 11 is associated with a more aggressive clinical course, higher recurrence rate, distal tracheobronchial spread, and a higher (though still low absolute) risk of malignant transformation to squamous cell carcinoma compared to HPV 6. The vertical transmission route (from maternal genital tract during delivery) explains the juvenile onset form.
Reference: Dhingra Diseases of Ear, Nose and Throat, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.