Juvenile-onset recurrent respiratory papillomatosis (JORRP) is caused by which HPV subtypes and is most commonly acquired:
- A HPV 16 and 18; by sexual transmission in adolescents
- B HPV 6 and 11; during passage through an infected birth canal ✓
- C HPV 31 and 33; by respiratory droplet in daycare settings
- D HPV 2 and 4; by direct contact with cutaneous warts
Correct answer: B. HPV 6 and 11; during passage through an infected birth canal
Explanation
Recurrent respiratory papillomatosis (RRP) in children is caused predominantly by HPV subtypes 6 and 11 (low-risk, non-oncogenic types, same as genital condylomata). Vertical transmission during vaginal delivery from a mother with genital HPV infection is the primary route. HPV 11 is associated with more aggressive disease and higher risk of airway involvement and malignant transformation. HPV 16 and 18 cause laryngeal carcinoma, not benign papillomatosis.
Reference: Dhingra Diseases of Ear, Nose and Throat, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.