A 25-year-old immunocompetent woman presents with multiple anogenital warts (condyloma acuminata) caused by HPV. The HPV subtypes responsible and the protein products mediating malignant transformation are:

• A HPV 6 and 11; E6 and E7 proteins binding p53 and Rb respectively
• B HPV 6 and 11 (low-risk); E6 and E7 cause malignant transformation in condylomata
• C HPV 16 and 18 (high-risk); E6 (degrades p53) and E7 (inactivates Rb/p105) ✓
• D HPV 31 and 33; L1 and L2 capsid proteins mediating p53 inactivation

Explanation

Anogenital condylomata are predominantly caused by low-risk HPV types 6 and 11, which rarely cause malignant transformation. High-risk HPV types 16 and 18 are responsible for the majority of cervical, vulvar, and anal cancers. E6 of high-risk HPV binds and degrades p53 (via ubiquitin-proteasome), while E7 binds and inactivates Rb (retinoblastoma protein), releasing E2F transcription factors and driving uncontrolled cell proliferation. The L1 capsid protein is the basis for HPV vaccines (Gardasil, Cervarix).

Reference: Neena Khanna Illustrated Synopsis of Dermatology & STD, 6th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.