A child presents with multiple papules on the trunk showing central umbilication. Histopathology reveals large cytoplasmic inclusions (Henderson-Paterson bodies). The causative agent belongs to which virus family?
- A Poxviridae — Molluscipoxvirus ✓
- B Herpesviridae
- C Papillomaviridae
- D Picornaviridae
Correct answer: A. Poxviridae — Molluscipoxvirus
Explanation
Molluscum contagiosum is caused by Molluscipoxvirus, a member of the Poxviridae family. Histopathology shows lobular invaginations of hyperplastic epidermis with large eosinophilic cytoplasmic inclusions — Henderson-Paterson (molluscum) bodies — which are cytoplasmic viral inclusion bodies displacing the nucleus to the periphery. The lesions spontaneously involute in immunocompetent children within 6-18 months. In HIV/immunocompromised patients, lesions can be giant and numerous, involving the face.
Reference: Neena Khanna Illustrated Synopsis of Dermatology & STD, 6th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.