A 25-year-old man is diagnosed with uncomplicated gonococcal urethritis. According to current guidelines, what is the recommended first-line treatment?

• A Ceftriaxone 500 mg IM single dose ✓
• B Ciprofloxacin 500 mg oral single dose
• C Azithromycin 1 g oral single dose
• D Penicillin G 2.4 MU IM single dose

Explanation

Current guidelines recommend ceftriaxone 500 mg IM as a single dose for uncomplicated gonorrhea. Fluoroquinolones like ciprofloxacin are no longer recommended due to widespread resistance. Azithromycin alone is insufficient for gonorrhea and is used primarily for chlamydial co-infection. Penicillin is not used due to beta-lactamase-producing strains of Neisseria gonorrhoeae.

Reference: Harrison's Principles of Internal Medicine, 21st ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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