Donovanosis (granuloma inguinale) is characterized histologically by which pathognomonic finding?

• A Multinucleate giant cells with ingested spirochetes
• B Intracytoplasmic inclusion bodies (elementary bodies) in endothelial cells
• C Caseous granulomas with Langhans cells and satellite lymphadenitis
• D Large mononuclear macrophages containing Donovan bodies (bipolar-staining rod-shaped organisms within vacuoles) ✓

Explanation

Donovanosis (caused by Klebsiella granulomatis, formerly Calymmatobacterium granulomatis) shows Donovan bodies — intracytoplasmic, bipolar-staining (safety pin appearance), encapsulated organisms within the vacuoles of large mononuclear histiocytes (Mikulicz cells). Diagnosis is made from tissue crush smear or biopsy stained with Giemsa or Wright stain. Treatment is azithromycin 1 g weekly or doxycycline 100 mg BD for at least 3 weeks until all lesions heal.

Reference: Neena Khanna Illustrated Synopsis of Dermatology & STD, 6th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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